In the realm of healthcare, the importance of data cannot be overstated. From understanding the efficacy of medications to improving patient outcomes, data serves as a cornerstone for informed decision-making. Real-world evidence (RWE), derived from the analysis of real-world data, emerges as a critical asset in this endeavour, offering insights that complement clinical trial data. Safety remains a paramount concern in healthcare, and RWE plays a pivotal role in augmenting safety surveillance efforts. While clinical trials provide valuable safety data under controlled conditions, they may not fully capture the spectrum of adverse events that manifest in real-world settings. RWE acts as a complementary tool for detecting and evaluating potential safety concerns associated with medical interventions. By analysing real-world data, researchers can uncover adverse events that may have been missed during clinical trials, facilitating proactive risk assessment and mitigation strategies. Moreover, RWE serves as a bridge between research and clinical practice, facilitating evidence-based decision-making at the point of care. By synthesizing real-world insights with clinical expertise, healthcare providers can make informed treatment decisions tailored to individual patient needs. Whether it’s optimizing medication regimens, adjusting dosages, or identifying alternative therapies, RWE empowers medical professionals to deliver personalized care that maximizes patient outcomes and safety. The integration of real-world data and evidence represents a paradigm shift in healthcare, unlocking new frontiers in patient care and drug development. By harnessing the power of RWE, stakeholders can gain deeper insights into treatment effectiveness, personalize patient care, and enhance safety surveillance efforts. As we navigate this evolving landscape, it is imperative to prioritize responsible data governance, ethical considerations, and interdisciplinary collaboration to harness the full potential of real-world insights in driving positive outcomes for patients worldwide.